Ultra- and Hyper-compact HII regions at 20 GHz

We present radio and infrared observations of 4 hyper-compact HII regions and 4 ultra-compact HII regions in the southern Galactic plane. These objects were selected from a blind survey for UCHII regions using data from two new radio surveys of the southern sky; the Australia Telescope 20 GHz survey (AT20G) and the 2nd epoch Molonglo Galactic Plane Survey (MGPS-2) at 843 MHz. To our knowledge, this is the first blind radio survey for hyper- and ultra-compact HII regions. We have followed up these sources with the Australia Telescope Compact Array to obtain H70-alpha recombination line measurements, higher resolution images at 20 GHz and flux density measurements at 30, 40 and 95 GHz. From this we have determined sizes and recombination line temperatures as well as modeling the spectral energy distributions to determine emission measures. We have classified the sources as hyper-compact or ultra-compact on the basis of their physical parameters, in comparison with benchmark parameters from the literature. Several of these bright, compact sources are potential calibrators for the Low Frequency Instrument (30-70 GHz) and the 100-GHz channel of the High Frequency Instrument of the Planck satellite mission. They may also be useful as calibrators for the Australia Telescope Compact Array, which lacks good non-variable primary flux calibrators at higher frequencies and in the Galactic plane region. Our spectral energy distributions allow the flux densities within the Planck bands to be determined, although our high frequency observations show that several sources have excess emission at 95 GHz (3 mm) that can not be explained by current models.Comment: 13 pages, 7 figures, accepted for publication in MNRA

An optical view of the filament region of Abell 85

We compare the distribution of optically and Halpha (Ha) selected galaxies in the Southern half of the nearby Abell 85 (A85) cluster with the recently discovered X-ray filament (XRF). We search for galaxies where star formation (SF) may have been triggered by interactions with intracluster gas or tidal pressure due to the cluster potential when entering the cluster. Our analysis is based on images obtained with CFHT MegaPrime/MegaCam (1x1 deg2 field) in four bands (ugri) and ESO 2.2mWFI (38'x36' field) in a narrow band filter corresponding to the redshifted Halpha (Ha) line and in a broad R-band filter. The LFs are estimated by statistically subtracting a reference field. Background contamination is minimized by cutting out galaxies redder than the observed red sequence in the g-i vs. i colour-magnitude diagram. The galaxy distribution shows a significantly flattened cluster, whose principal axis is slightly offset from the XRF. The analysis of the broad band LFs shows that the filament region is well populated. The filament is also independently detected as a gravitationally bound structure by the Serna & Gerbal hierarchical method. 101 galaxies are detected in Ha, among which 23 have spectroscopic redshifts in the cluster, 2 have spectroscopic redshifts higher than the cluster and 58 have photometric redshifts that tend to indicate that they are background objects.The 23 galaxies with spectroscopic redshifts in the cluster are mostly concentrated in the South part of the cluster and along the filament. We find a number of galaxies showing evidence for SF in the XRF, and all our results are consistent with the previous hypothesis that the XRF in A85 is a gravitationally bound structure made of groups falling on to the main cluster.Comment: Accepted in A&A. 39 pages, 107 figures. Full resolution images available at ftp://ftp.iap.fr/pub/from_users/gam/A85

A Fully-Coupled Electro-Mechanical Whole-Heart Computational Model: Influence of Cardiac Contraction on the ECG

The ECG is one of the most commonly used non-invasive tools to gain insights into the electrical functioning of the heart. It has been crucial as a foundation in the creation and validation of in silico models describing the underlying electrophysiological processes. However, so far, the contraction of the heart and its influences on the ECG have mainly been overlooked in in silico models. As the heart contracts and moves, so do the electrical sources within the heart responsible for the signal on the body surface, thus potentially altering the ECG. To illuminate these aspects, we developed a human 4-chamber electro-mechanically coupled whole heart in silico model and embedded it within a torso model. Our model faithfully reproduces measured 12-lead ECG traces, circulatory characteristics, as well as physiological ventricular rotation and atrioventricular valve plane displacement. We compare our dynamic model to three non-deforming ones in terms of standard clinically used ECG leads (Einthoven and Wilson) and body surface potential maps (BSPM). The non-deforming models consider the heart at its ventricular end-diastatic, end-diastolic and end-systolic states. The standard leads show negligible differences during P-Wave and QRS-Complex, yet during T-Wave the leads closest to the heart show prominent differences in amplitude. When looking at the BSPM, there are no notable differences during the P-Wave, but effects of cardiac motion can be observed already during the QRS-Complex, increasing further during the T-Wave. We conclude that for the modeling of activation (P-Wave/QRS-Complex), the associated effort of simulating a complete electro-mechanical approach is not worth the computational cost. But when looking at ventricular repolarization (T-Wave) in standard leads as well as BSPM, there are areas where the signal can be influenced by cardiac motion of the heart to an extent that should not be ignored

Contracting with General Dental Services: a mixed-methods study on factors influencing responses to contracts in English general dental practice

Background: Independent contractor status of NHS general dental practitioners (GDPs) and general medical practitioners (GMPs) has meant that both groups have commercial as well as professional identities. Their relationship with the state is governed by a NHS contract, the terms of which have been the focus of much negotiation and struggle in recent years. Previous study of dental contracting has taken a classical economics perspective, viewing practitioners’ behaviour as a fully rational search for contract loopholes. We apply institutional theory to this context for the first time, where individuals’ behaviour is understood as being influenced by wider institutional forces such as growing consumer demands, commercial pressures and challenges to medical professionalism. Practitioners hold values and beliefs, and carry out routines and practices which are consistent with the field’s institutional logics. By identifying institutional logics in the dental practice organisational field, we expose where tensions exist, helping to explain why contracting appears as a continual cycle of reform and resistance. Aims: To identify the factors which facilitate and hinder the use of contractual processes to manage and strategically develop General Dental Services, using a comparison with medical practice to highlight factors which are particular to NHS dental practice. Methods: Following a systematic review of health-care contracting theory and interviews with stakeholders, we undertook case studies of 16 dental and six medical practices. Case study data collection involved interviews, observation and documentary evidence; 120 interviews were undertaken in all. We tested and refined our findings using a questionnaire to GDPs and further interviews with commissioners. Results: We found that, for all three sets of actors (GDPs, GMPs, commissioners), multiple logics exist. These were interacting and sometimes in competition. We found an emergent logic of population health managerialism in dental practice, which is less compatible than the other dental practice logics of ownership responsibility, professional clinical values and entrepreneurialism. This was in contrast to medical practice, where we found a more ready acceptance of external accountability and notions of the delivery of ‘cost-effective’ care. Our quantitative work enabled us to refine and test our conceptualisations of dental practice logics. We identified that population health managerialism comprised both a logic of managerialism and a public goods logic, and that practitioners might be resistant to one and not the other. We also linked individual practitioners’ behaviour to wider institutional forces by showing that logics were predictive of responses to NHS dental contracts at the dental chair-side (the micro level), as well as predictive of approaches to wider contractual relationships with commissioners (the macro level) . Conclusions: Responses to contracts can be shaped by environmental forces and not just determined at the level of the individual. In NHS medical practice, goals are more closely aligned with commissioning goals than in general dental practice. The optimal contractual agreement between GDPs and commissioners, therefore, will be one which aims at the ‘satisfactory’ rather than the ‘ideal’; and a ‘successful’ NHS dental contract is likely to be one where neither party promotes its self-interest above the other. Future work on opportunism in health care should widen its focus beyond the self-interest of providers and look at the contribution of contextual factors such as the relationship between the government and professional bodies, the role of the media, and providers’ social and professional networks. Funding: The National Institute for Health Research Health Services and Delivery Research programme

Gravity-wave momentum fluxes in the mesosphere over Ascension Island (8° S, 14° W) and the anomalous zonal winds of the semi-annual oscillation in 2002

Anomalously strong westward winds during the first phase of the equatorial mesospheric semi-annual oscillation (MSAO) have been attributed to unusual filtering conditions producing exceptional gravity-wave fluxes. We test this hypothesis using meteor-radar measurements made over Ascension Island (8° S, 14° W). An anomalous wind event in 2002 of −85.5 ms⁻¹ occurred simultaneously with the momentum fluxes of high-frequency gravity waves reaching the largest observed westward values of −29 m² s⁻² and strong westward wind accelerations of −510 ms⁻¹ day⁻¹. However, despite this strong wave forcing during the event, no unusual filtering conditions or significant increases in wave-excitation proxies were observed. Further, although strong westward wave-induced accelerations were also observed during the 2006 MSAO first phase, there was no corresponding simultaneous response in westward wind. We thus suggest that strong westward fluxes/accelerations of high-frequency gravity waves are not always sufficient to produce anomalous first-phase westward MSAO winds and other forcing may be significant

Electro-mechanical whole-heart digital twins: A fully coupled multi-physics approach

Mathematical models of the human heart are evolving to become a cornerstone of precision medicine and support clinical decision making by providing a powerful tool to understand the mechanisms underlying pathophysiological conditions. In this study, we present a detailed mathematical description of a fully coupled multi-scale model of the human heart, including electrophysiology, mechanics, and a closed-loop model of circulation. State-of-the-art models based on human physiology are used to describe membrane kinetics, excitation-contraction coupling and active tension generation in the atria and the ventricles. Furthermore, we highlight ways to adapt this framework to patient specific measurements to build digital twins. The validity of the model is demonstrated through simulations on a personalized whole heart geometry based on magnetic resonance imaging data of a healthy volunteer. Additionally, the fully coupled model was employed to evaluate the effects of a typical atrial ablation scar on the cardiovascular system. With this work, we provide an adaptable multi-scale model that allows a comprehensive personalization from ion channels to the organ level enabling digital twin modeling

Cognitive facilitation following intentional odor exposure

This paper reviews evidence that, in addition to incidental olfactory pollutants, intentional odor delivery can impact cognitive operations both positively and negatively. Evidence for cognitive facilitation/interference is reviewed alongside four potential explanations for odor-induced effects. It is concluded that the pharmacological properties of odors can induce changes in cognition. However, these effects can be accentuated/attenuated by the shift in mood following odor exposure, expectancy of cognitive effects, and cues to behavior via the contextual association with the odor. It is proposed that greater consideration is required in the intentional utilization of odors within both industrial and private locations, since differential effects are observed for odors with positive hedonic qualities

A computational model of rabbit geometry and ECG: Optimizing ventricular activation sequence and APD distribution

Computational modeling of electrophysiological properties of the rabbit heart is a commonly used way to enhance and/or complement findings from classic lab work on single cell or tissue levels. Yet, thus far, there was no possibility to extend the scope to include the resulting body surface potentials as a way of validation or to investigate the effect of certain pathologies. Based on CT imaging, we developed the first openly available computational geometrical model not only of the whole heart but also the complete torso of the rabbit. Additionally, we fabricated a 32-lead ECG-vest to record body surface potential signals of the aforementioned rabbit. Based on the developed geometrical model and the measured signals, we then optimized the activation sequence of the ventricles, recreating the functionality of the Purkinje network, and we investigated different apico-basal and transmural gradients in action potential duration. Optimization of the activation sequence resulted in an average root mean square error between measured and simulated signal of 0.074 mV/ms for all leads. The best-fit T-Wave, compared to measured data (0.038 mV/ms), resulted from incorporating an action potential duration gradient from base to apex with a respective shortening of 20 ms and a transmural gradient with a shortening of 15 ms from endocardium to epicardium. By making our model and measured data openly available, we hope to give other researchers the opportunity to verify their research, as well as to create the possibility to investigate the impact of electrophysiological alterations on body surface signals for translational research

Oxytocin exerts harmful cardiac repolarization prolonging effects in drug-induced LQTS

Background: Oxytocin is used therapeutically in psychiatric patients. Many of these also receive anti-depressant or anti-psychotic drugs causing acquired long-QT-syndrome (LQTS) by blocking HERG/IKr. We previously identified an oxytocin-induced QT-prolongation in LQT2 rabbits, indicating potential harmful effects of combined therapy. We thus aimed to analyze the effects of dual therapy with oxytocin and fluoxetine/risperidone on cardiac repolarization. Methods: Effects of risperidone, fluoxetine and oxytocin on QT/QTc, short-term variability (STV) of QT, and APD were assessed in rabbits using in vivo ECG and ex vivo monophasic AP recordings in Langendorff-perfused hearts. Underlying mechanisms were assessed using patch clamp in isolated cardiomyocytes. Results: Oxytocin, fluoxetine and risperidone prolonged QTc and APD in whole hearts. The combination of fluoxetine + oxytocin resulted in further QTc- and APD-prolongation, risperidone + oxytocin tended to increase QTc and APD compared to monotherapy. Temporal QT instability, STVQTc was increased by oxytocin, fluoxetine / fluoxetine + oxytocin and risperidone / risperidone + oxytocin. Similar APD-prolonging effects were confirmed in isolated cardiomyocytes due to differential effects of the compounds on repolarizing ion currents: Oxytocin reduced IKs, fluoxetine and risperidone reduced IKr, resulting in additive effects on IKtotal-tail. In addition, oxytocin reduced IK1, further reducing the repolarization reserve. Conclusion: Oxytocin, risperidone and fluoxetine prolong QTc / APD. Combined treatment further prolongs QTc/APD due to differential effects on IKs and IK1 (block by oxytocin) and IKr (block by risperidone and fluoxetine), leading to pronounced impairment of repolarization reserve. Oxytocin should be used with caution in patients in the context of acquired LQTS. © 2022 The Author